New Projects

The Lindberg lab is currently recruiting PhD students and Post-doctoral fellows for the following two research streams:

1. Immunomodulation in Osteoarthritis

immunomodulation in osteoarthritis
Activated U937 monocytes stained with DAPI.

We explore the role of the innate immunity and inflammation in osteoarthritis and downstream tissue regeneration using sophisticated tissue models to replicate both healthy and diseased cartilage microenvironments. The project primarily focuses on modulating the localization, migration and phenotypic stability of synovial macrophages using advanced biofabrication technologies and bioactive materials. This offers new avenues to drive successful cartilage repair within highly diseased osteoarthritic environments.

2. Bone Marrow Tissue Engineering

bone marrow tissue engineering
Femoral head (rat) stained with Alcian blue/Picrosirius red.

We explore the engineering of the red bone marrow niche using a delicate mix of spongy biomaterials to regenerate a highly vascular fibrous tissue containing hematopoietic stem cells and supportive cells (fibroblast-, endothelial-, adipose-, osteoblasts- and/or stromal cells). Bone marrow is both an important part of the bone interior as well as the lymphatic system, offering a unique strategy to treat a wide range of both musculoskeletal and hematological diseases.